Polymeric a controlled release profile of drug thus

Polymeric
sutures have been studied widely in the recent years due to their advanced
biological properties. Sutures are biomaterial devices used for a wide
range of applications including approximating tissues, connecting hollow
structures and for the ligation of blood vessels. Due to the adaptability of
polymeric sutures to different conditions, they are preferred over other
materials for targeted drug delivery. Sutures have been found to be a
remarkable strategy for the delivery of antibacterial agents or
anti-inflammatory drugs to the surgical site. This system provides
a controlled release profile of drug thus achieving high local drug concentrations
without excessive systemic levels. Polymeric sutures when in used surgical procedures
they do not require separate procedure for placing the drug system like
implants into the surgical bed. Thus avoiding the unwanted generation of nidus
for infection and also prevents hindering the wound healing process. There are two
main types of polymeric sutures: Absorbable sutures and Non-Absorbable sutures.
Among them Absorbable/Biodegradable sutures have undergone immense research
since they have potential for effective drug delivery. On the basis of their
origin, absorbable sutures are further classified into 2 types: Natural and Synthetic.
Natural absorbable suture like catgut is obtained from the
connective tissue of beef or sheep intestines. Synthetically derived absorbable
sutures are fabricated using polymers like polyglycolic acid, polylactic acid, PLGA or poly(lactic-co-glycolic
acid) and Polydioxanone, poliglecaprone
25 and Vicryl – Rapide. These sutures
absorb anywhere between ten days to eight weeks depending on the material
used in making them. Non-absorbable sutures are
made up of Nylon, polyester, Polyvinylidene fluoride (PVDF), polypropylene,
ultra-high molecular weight polyethylene (UHMWPE) etc. The material for
fabrication of these sutures are selected depending on their intended
application. Silk is the original non-absorbable suture material derived from
an organic protein called fibroin. The design of suture is a critical parameter
because it finally affects the suture quality. Physical and mechanical
properties like suture size, tensile strength, stiffness etc is important in
suture selection in order to avoid unexpected breakage during use. Drugs or biomolecules are loaded in/onto
the sutures either during fabrication or after fabrication, using various
techniques namely Electrospinning, Melt spinning, Dip coating and Radiation
Grafting. Recently reported polymeric sutures provide controlled drug release
of various therapeutic agents like antimicrobials, natural extracts, proteins,
transcription factors, plant stem cells. For achieving a systematic and
controlled delivery of drug through this system it should be designed in a way
that it retains its mechanical integrity as long as it is required to ensure
complete wound healing. The
studies for improving mechanical properties of sutures and designing them with
all desirable properties is still under investigation.

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